Problem: The “What’s This” feature only opens to the first page of the manual in Adobe Ready XI.

Solution: Open your Adobe Reader XI

In the upper left corner:

Click on Edit
Preferences
Security (Enhanced)

Check only the following boxes:

In the upper left corner:

Next click on General and only have the marked boxes checked and click on “Select Default PDF Handler”

In the upper left corner:

In the upper left corner:

In the “Select Adobe Product” you should have two option:
Adobe Reader XI (11.0.17) MUI
And
Adobe Acrobat XI Standard

Note: If the above is set to “Adobe Acrobat XI Standard” and the “What’s This” feature is working, great. If not, select “Adobe Reader XI (11.0.17) MUI” and click “Apply.”